Medication Assisted Treatment (MAT) for Opioid Use Disorder

Well supported scientific evidence has shown that medications in combination with behavioral therapy are effective in the treatment of opioid use disorder. Despite this evidence, these medications are underutilized and demand far outweighs supply. The FDA has approved 3 medications for this purpose: methadone, buprenorphine, and naltrexone.

SAMHSA provides an overview and resources for Medication Assisted Treatment.
These resources include:

  • MAT Checklist
  • Expanding the Use of Medications to Treat Individuals with SUDs
  • Procedures for MAT of Alcohol or Opioid Dependence in Primary Care
  • Getting Started with MAT with Lessons from Advancing Recovery
  • Opioid Overdose Prevention Toolkit
  • TIP 40: Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction
  • TIP 43: MAT for Opioid Addiction in Opioid Treatment Programs
  • TIP 49: Incorporating Alcohol Pharmacotherapies into Medical Practice

Other SAMHSA Resources:

American Society of Addiction Medicine (ASAM): National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use (2015) and other clinical resource materials

Federation of State Medical Boards: Model Policy on Data 2000 and Treatment of Opioid Addiction in the Medical Office


American Association for the Treatment of Opioid Dependence (AATOD) White Papers Discusses and Compares the Models:

  • Whitepaper 1: Model of Integrated Patient Care through OTPs and DATA 2000 Practices
  • Whitepaper 2: Integrated Service Delivery Models for OTPs in an Era of Increasing Opioid Addiction, Health Reform, and Parity
  • Whitepaper 3: Increasing Access to MAT for Opioid Addiction in Drug Courts and Correctional

CMS: Designing Medicaid Health Homes for Individuals with Opioid Dependency: Considerations for States (features MD, RI, and VT)